Lab Director
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Mahesh H. Mankani, M.D., FACS
Associate Professor of Surgery
Division of Plastic and Reconstructive Surgery
Contact Information
BiographyEducation
- Stanford University, Stanford, California, B.S., 1983
- University of Hawaii, School of Medicine, Honolulu, Hawaii, M.D., 1988
Residencies
- The University of Chicago, Chicago, Illinois, Residency, General Surgery, 1988-1992
- Georgetown University Medical Center, Residency, Plastic and Reconstructive Surgery, Washington DC, 1993-1994
- Georgetown University Medical Center, Chief Residency, Plastic and Reconstructive Surgery, Washington DC, 1994-1995,
Fellowships
- The University of Chicago, Chicago, Illinois, Fellowship, Burn Surgery, 1992-1993
- Brigham and Women's Hospital; Boston, Massachusetts,Fellowship, Hand and Microsurgery, 1995-1996
- Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Fellow, 1996-2000
Board Certification
- American Board of Plastic Surgery, 2002
- American Board of Plastic Surgery, Subspecialty in Hand Surgery, 2003
Clinical Expertise
- Abdominoplasty
- Acute Burn Reconstruction
- Acute Trauma Hand Surgery
- Breast Augmentation
- Breast Lift
- Breast Reconstruction
- Breast Reduction
- Facial Rejuvenation
- Hand and Microvascular Surgery
- Late Burn Reconstruction
- Liposuction
- Microsurgery
- Microvascular Reconstruction
- Pediatric Hand Surgery
- Reconstructive Hand Surgery
- Rheumatoid Hand Disorders
- Skin Cancer Reconstruction
- Wound healing
Research Interests
Exploring role of bone marrow stromal cells (BMSCs) in bone formation and remodeling
Enhancing normal bone formation in patients with osteoporosis
Treatment of bone abnormalities with cell-based therapies
View Reseach Profile at UCSF Clinical & Translational Science Institute
Website Links
Biography
Dr. Mahesh Mankani is Associate Professor of Surgery in Residence and a Principal Investigator at the UCSF Surgical Research Laboratory at SFGH. Dr. Mankani is a graduate of Stanford University and the University of Hawaii School of Medicine. He did his General Surgery Residency at the University of Chicago where he also completed a Fellowship in Burn Surgery. He then went on to the Georgetown University Medical Center where he completed his Plastic and Reconstructive Surgical Residency.
His Fellowship in Hand and Microsurgery was done at Brigham and Women's Hospital; his Clinical Fellowship in Surgery at the Harvard Medical School; and his Craniofacial and Skeletal Disease Fellowship at the NIH. Dr. Mankani's area of clinical expertise is in Plastic and Reconstructive Surgery, Hand Surgery, and Burn Surgery. His research focuses on the role of bone marrow stromal cells in bone formation and regeneration.
Research Summary
Since Dr. Mankani's appointment as a Fellow in the Craniofacial and Skeletal Diseases Branch at the National Institute of Dental and Craniofacial Research (NIH), and then during his tenure here on the UCSF faculty, his long-term goal has been to establish an interdisciplinary program to treat patients' bone abnormalities with cell-based therapies. He has established an active research program exploring the role of bone marrow stromal cells (BMSCs) in bone formation and remodeling, focusing on ways to enhance normal bone formation in patients with segmental bone defects and with osteoporosis.
Dr. Mankani has focused his research in two areas: 1) developing techniques to engraft BMSCs and engineer bone, and 2) describing the role of BMSCs in bone formation and repair.
Selected Publications
- Mankani MH, Krebsbach PH, Satomura K, Kuznetsov SA, Hoyt R, Robey PG. Pedicled bone flap formation by bone marrow stromal cells. Arch Surg. 2001;136(3):263-70.
- Mankani MH, Kuznetsov SA, Avila N, Kingman A, Robey PG. Bone formation in transplants of human bone marrow stromal cells and hydroxyapatite-tricalcium phosphate: prediction with quantitative CT in mice. Radiology. 2004;230(2):369-376.
- Mankani MH, Kuznetsov SA, Shannon B, Nalla RK, Ritchie RO, Qin Y, Gehron Robey P. Canine Cranial Reconstruction Using Autologous Bone Marrow Stromal Cells. Am J Path. 2006;168(2):542-550.
- Mankani MH, Kuznetsov SA, Wolfe RM, Marshall GW, Gehron Robey P. In vivo bone formation by human bone marrow stromal cells: reconstruction of the mouse calvarium and mandible. Stem Cells. 2006; 24(9):2140-2149.
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